Theres quit a few factors in there. Depending on the year LS1 you might get a LS6 intake. If not that intake what are you thinking about? FAST?, Weiand? Chip is another optiong, Diablo, Hyper, etc. With LT's, straight pipe, LS6 intake, and a decent tune i would say a good 300-350rwhp through and auto. I wouldnt mate it to a th350 though but instead a th400 or a 4l60 should be fine. The th400 in some peoples opinions is a beefy 4L80E with an o/d. Assuming the s-10s come with a 10 bolt i think with some good axels you should be more than fine. my $0.02. Good Luck